Peripheral intravenous catheter related phlebitis is the most common side effect of peripheral catheterizations. In this study, the effect of different variables on the severity of peripheral intravenous catheter related phlebitis have been investigated during one year period (2011 - 2012). Patients undergoing peripheral intravenous catheter procedure in surgery, pediatric, internal disease, gynecology, emergency, infectious, ICU and CCU wards wereselected for study protocol. The correlation between the severity of peripheral intravenous catheter related phlebitis and the variables such as underlying disease, injected drug, duration of catheterization, Intravenous (IV) line location, type of peripheral intravenous catheter, sex and age were recorded in all of patients with peripheral intravenous catheter . Severity of peripheral intravenous catheter related phlebitis was the most in patients with foot IV line, ICU&CCU wards and in the diabetic patients. However, there was no significant correlation between the severity of peripheral intravenous catheter related phlebitis and sex, age, type of drug, duration of catheterization and type of peripheral intravenous catheter. 
Use of IV catheter is recommended be in hand and wrist especially in elderly and diabetic.